Cancer is a genetic and developmental disorder. The recent advents of systematic sequencing studies have revealed thousands of somatic mutations, hundreds of chromosome rearrangements and copy number variants in the cancer genomes. The genomic changes can differ markedly between individual cancers, even within a particular cancer type, individual tumours often display wide variations. Heterogeneity of cancer or cancer cells is the well observed phenomenon and is considered the major hurdle for successful treatment. Mutational clonal evolution and cancer stem cell models could only partially explain the ubiquitous heterogeneous tumour cell population.
Journal of Stem Cell Research And Therapy
Dr Martha Castro's Counter (SD: 10/28/11)